Fibromyalgia syndrome is not fatal, but it is chronic and there has not yet been developed any reliable treatment. Cases of spontaneous recovery have been reported, but are very rare. Any improvements usually will only be limited to the gravity of certain symptoms.

The patient diagnosed with Fibromyalgia syndrome will have to cope with the fact that he most likely will never regain his full mental or physical capacities.
He will have to accept that a major part of his daily routines must include extended resting periods and light exercises and that he has to avoid any kind of stress or otherwise has to realize immediate intensification of symptoms, including sleeping disorders and fatigue.

All this will in most cases have a severe impact on the professional as well as the personal and family life of the patient.
Many Fibromyalgia patients will require lifelong assistance and the overwhelming majority will prefer a continuous drug therapy to alleviate symptoms on the one hand and reduce the burden for colleagues and family members on the other. Traditionally selective serotonin reuptake inhibitors (SSRIs) and/or selective norepinephrine reuptake inhibitors (SNRIs) are the medications of choice, but recently more experimental paths have been followed, comprising marihuana (THC) and kratom (mitragyna speciosa), a leaf with strong painkilling and sedating properties.